Pharmacokinetic analysis
نویسندگان
چکیده
Silymarin, an extract of the seeds of Silybum marianum L. (milk thistle), is used for treatment of liver diseases. It contains several active flavonolignans; the major are silybin, which is a mixture of diastereomers A and B, and silychristin. Low bioavailability of silybin and silychristin is related to low water solubility of these compounds. In order to enhance the solubility, S. marianum dry extract was coground with two polymers: crospovidone (PVP-CL) and carboxymethylcellulose (Ac-Di-Sol) in 1:3 dry extract-to-polymer weight ratios [1].
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